Committee on Medical Internal Radiation Dose (MIRD)
Radiation dosimetry provides the fundamental quantities used for radiation protection, risk assessment, and treatment planning. The MIRD Committee develops standard methods, models, assumptions, and mathematical schema for assessing internal radiation doses from administered radiopharmaceuticals. The MIRD approach simplifies the problem of assessing dose for many different radionuclides—each with its unique radiological characteristics and chemical properties as labeled compounds—in the highly diverse biological environment represented by the human body, internal organs, tissues, and fluid compartments. The virtue of the MIRD approach is that it systematically reduces complex dosimetric analyses to methods that are relatively simple to use, including software tools for experimental and clinical use.
- Develop and provide a standardized framework and methodology for calculation of internal dose quantities in nuclear medicine.
- Compile, evaluate and disseminate data needed to implement standardized internal dosimetry methods including radionuclide decay properties and emissions, energy absorbed fractions and anatomic models.
- Collect and assess experimental and peer-reviewed data to publish dose estimate reports for selected new radiopharmaceuticals which significantly impact the current practice of nuclear medicine.
- Provide peer-reviewed evaluations of proposed new dosimetry models and methods including correlating dose with biological response for cellular, animal and clinical trials data.
- Address other critical and timely dosimetry issues that may impact the current practice of nuclear medicine.
- Develop, test and publish software and internet tools that implement MIRD calculation models and techniques including dose-response data and biological effective or equivalent dose quantities.
- Actively work with other national and international committees through joint meetings and symposia to establish uniformity in dosimetry models, techniques, named special quantities and units of dose and biological response.
Recent Key Accomplishments:
Kidney Dose-Response Webtool:
An interactive internet-based application has been developed which implements the kidney dosimetry model described in MIRD Pamphlet No. 20.
The Webtool requires a login and password. The login is currently 'mird' and the password is 'MIRD'.
If you have difficulty logging in, please contact B. Wessels at Barry.Wessels@uhhospitals.org.
MIRD Committee Related Pages:
MIRD Books for Sale
MIRD Decay Schemes 2nd Edition (2008)This updated edition of MIRD: Radionuclide Data and Decay Schemes is an essential sourcebook for radiation dosimetry and understanding the properties of radionuclides.
MIRD Head and Brain Dosimetry (1999)Addresses available neuroimaging applications in nuclear medicine internal dosimetry for both children and adults. Contains comprehensive tables of absorbed fractions and S values for all models and radiopharmaceuticals, along with steps for verifying calculations and tabulations.
MIRD Supplement to JNM (1999)This compilation of MIRD Pamphlet numbers 14 (revised) through 17 covers the urinary bladder model for radiation dose calculations, radionuclide S values in a revised dosimetric model of the adult head and brain, quantitative radiopharmaceutical biodistribution data acquisition and analysis, and the dosimetry of nonuniform activity distributions.
MIRD Cellular S Values (1997)Provides tools necessary to estimate the absorbed dose at the cellular level from intracellularly localized radionuclides using cellular S values for emitters of monoenergetic electrons and alpha particles and almost all radionuclides.
MIRD Primer for Absorbed Dose Calculations, rev. ed (1991)The MIRD Primer is unquestionably the standard reference on absorbed dosage of radiopharmaceuticals in humans, offering a thorough review of absorbed dose calculations used in the application of radiopharmaceuticals to medical studies.