About SNM
Governance Overview
Medical Internal Radiation Dose (MIRD) Committee
Description
Radiation dosimetry provides the fundamental quantities used for radiation protection, risk assessment, and treatment planning. The MIRD Committee develops standard methods, models, assumptions, and mathematical schema for assessing internal radiation doses from administered radiopharmaceuticals. The MIRD approach simplifies the problem of assessing dose for many different radionuclides---each with its unique radiological characteristics and chemical properties as labeled compounds---in the highly diverse biological environment represented by the human body, internal organs, tissues, and fluid compartments. The virtue of the MIRD approach is that it systematically reduces complex dosimetric analyses to methods that are relatively simple to use, including software tools for experimental and clinical use.
Goals and objectives:
- Develop and publish standardized, apposite methods for calculating internal radiation doses from diagnostic and therapeutic radiopharmaceuticals
- Compile and disseminate supporting data needed to implement such methods, such as radionuclide decay properties and emissions, energy absorbed fractions, and anatomic models
- Develop and publish software tools that implement MIRD calculations and models
- Assess and publish dosimetry for new radiopharmaceuticals
- Develop methods for correlating dose with response to evaluate the relevance of factors, in addition to absorbed dose, that influence biological response from internal emitters
- Address other critical and timely dosimetry issues that may impact the practice of nuclear medicine
Committee Information
Committee Reports
Recent Key Accomplishments:
- MIRD Pamphlet No. 22: Radiobiology and Dosimetry of Alpha-Particle Emitters for Targeted Radionuclide Therapy.
- Dynamic Bladder Software Tool available to members of the Society for download
- MIRD Pamphlet No. 19: Absorbed Fractions and Radionuclide S Values for Six Age-Dependent Multiregion Models of the Kidney. J Nucl Med 2003; 44:1113-1147.
- MIRD Dose Estimate Report No. 19: Radiation Absorbed Dose Estimates from 18F-FDG. J Nucl Med 2002; 43:210-214.
- MIRD Pamphlet No. 18. Administered Cumulated Activity for Ventilation Studies. JNM 2001; 42:520-526.
MIRD Committee Related Pages:
- 2009-2010 MIRD Committee Internship Program
- MIRD Publications Available Online
- Dynamic Bladder Software Tool
- Loevinger-Berman Award Presentation
- MIRD Sponsored Continuing Education Courses
- Annual Report
| Members | ||
| George Sgouros, PhD | Chairperson | |
| Wesley E. Bolch, PhD | Secretary | |
| Aaron Bertrand Brill, MD, PhD | Committee Member | |
| Yuni K. Dewaraja, PhD | Committee Member | |
| Darrell R. Fisher, PhD | Committee Member | |
| Roger W. Howell, PhD | Committee Member | |
| Ruby Meredith, MD, PhD | Committee Member | |
| Barry W. Wessels, PhD | Committee Member | |
| Pat B. Zanzonico, PhD | Committee Member | |