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Governance Overview

Medical Internal Radiation Dose (MIRD) Committee

Medical Internal Radiation Dose (MIRD) Committee

Description

Radiation dosimetry provides the fundamental quantities used for radiation protection, risk assessment, and treatment planning. The MIRD Committee develops standard methods, models, assumptions, and mathematical schema for assessing internal radiation doses from administered radiopharmaceuticals. The MIRD approach simplifies the problem of assessing dose for many different radionuclides---each with its unique radiological characteristics and chemical properties as labeled compounds---in the highly diverse biological environment represented by the human body, internal organs, tissues, and fluid compartments. The virtue of the MIRD approach is that it systematically reduces complex dosimetric analyses to methods that are relatively simple to use, including software tools for experimental and clinical use.

Goals and objectives:

  • Develop and publish standardized, apposite methods for calculating internal radiation doses from diagnostic and therapeutic radiopharmaceuticals
  • Compile and disseminate supporting data needed to implement such methods, such as radionuclide decay properties and emissions, energy absorbed fractions, and anatomic models
  • Develop and publish software tools that implement MIRD calculations and models
  • Assess and publish dosimetry for new radiopharmaceuticals
  • Develop methods for correlating dose with response to evaluate the relevance of factors, in addition to absorbed dose, that influence biological response from internal emitters
  • Address other critical and timely dosimetry issues that may impact the practice of nuclear medicine

Committee Information

Committee Reports

Recent Key Accomplishments:

MIRD Committee Related Pages:


Members
George Sgouros, PhD Chairperson
Wesley E. Bolch, PhD Secretary
Aaron Bertrand Brill, MD, PhD Committee Member
Yuni K. Dewaraja, PhD Committee Member
Darrell R. Fisher, PhD Committee Member
Roger W. Howell, PhD Committee Member
Ruby Meredith, MD, PhD Committee Member
Barry W. Wessels, PhD Committee Member
Pat B. Zanzonico, PhD Committee Member